【中文摘要】 【目的】研究IFN-α是否具有抗日本血吸虫病肝纤维化的作用及其疗效，并与疗效肯定的IFN-γ进行比较，从而寻找疗效肯定、价格低廉的抗血吸虫病肝纤维化药物，减轻患者经济负担；填补我国在应用IFN-α治疗日本血吸虫病肝纤维化研究方面的空白。 【方法】100只成年雄性IcR小鼠随机分作A、B、C、D、E共5组，每组20只。将血吸虫尾蚴(每鼠20±2条)经腹部皮肤攻击感染B、C、D、E组小鼠。10W后，称取体重并宰杀B组20只小鼠和随机抽取的A组10只小鼠，验证感染鼠造模是否成功并留取各鼠肝组织备检。C、D、E组各小鼠均以吡喹酮(100mg·kg~(-1)体重)一次性灌胃杀虫，继而分别以IFN-α、IFN-γ和等容量的生理盐水每日1次经小鼠颈背部皮下注射治疗；用药8W后，同法处理C、D、E组及A组剩余的小鼠并留取肝组织保存备检：肝组织分别作苏木素-伊红(HE)染色和苦味酸-酸性品红(VG)染色，观察、分析各感染组小鼠肝脏虫卵肉芽肿大小及各组小鼠肝脏内胶原沉积情况：采用《慢性肝炎肝纤维化半定量计分(SSS)方案》对小鼠肝脏纤维化程度进行评分，观察两种干扰素的治疗效果。 【结果】治疗前后，...

【英文摘要】 [Objective] To observe the effect of IFN-α on the inhibition of schistosomiasis japonica hepatic fibrosis in mice and the degree of it. To look for a kind of interferons which has better effect and is in a low price to lighten the economic burden of patients, by comparing with the IFN-γ which is well known that it has a affirmative curative effect on hepatic fibrosis. To acquire experimental data to treat this disease with IFN-α in China at the first time. [Methods] 100 mature male IcR strain mice were r...