【中文摘要】 目的：探讨慢性乙型肝炎病毒(HBV)携带者HBV前C区nt1896位点突变对宿主外周血T淋巴细胞亚群的影响。 方法：检测慢性HBV携带者HBV前C区nt1896位点突变及外周血T淋巴细胞亚群，以HBV前C区变异有无分组，比较T淋巴细胞亚群变化，再分别以HBeAg表达不同、年龄、性别及HBVDNA载量不同分组，比较HBV前C区变异阳性检出率及T淋巴细胞亚群。 结果：慢性HBV携带者较正常对照组CD3~+T淋巴细胞百分比差异无统计学意义(t=1.202，P=0.232)，CD4~+T淋巴细胞百分比(t=2.725，P=0.007)、CD4~+／CD8~+T细胞比值(t=2.546，P=0.012)降低，CD8~+T细胞百分比升高(t=2.606，P=0.010)。前C区变异组较无变异组CD3~+T细胞无差异(P=0.789)，CD4~+／CD8~+T细胞比值明显降低(P=0.033)，CD4~+T细胞有下降趋势、CD8~+T细胞有升高趋势。HBeAg阴性的慢性HBV携带者前C区变异阳性检出率为56.1％，HBeAg阳性的慢性HBV携带者较HBeAg阴性组，CD4~+T细胞下降(P=...

【英文摘要】 OBJECTIVE: To explore the relationship between the changes of T cell subsets and HBV precore region 1896 mutation in chronic HBV carriers. METHODS: HBV precore region 1896 mutation and peripheral T-cell subsets were examined in chronic HBV carriers. The results of peripheral T-cell subsets were compared among groups based on HBV precore region 1896 mutation status, HBeAg, age, *** and the quantities of HBV DNA. RESULTS: In comparison with those in health controls, the percentage of CD3~+T lymphocyte c...