【中文摘要】 目的 观察滑石粉联合顺铂胸腔内灌注治疗恶性胸腔积液的疗效及毒副反应。 方法 将33例恶性胸腔积液患者随机分为2组，滑石粉联合顺铂治疗组(治疗组)15例，顺铂治疗组(对照组)18例，所有患者均采用中心静脉导管进行胸腔闭式引流，待胸腔积液引流彻底后给予胸腔内给药，滑石粉联合顺铂治疗组：给予生理盐水30ml+滑石粉3～4g，半小时后再给予生理盐水30ml+顺铂60mg。顺铂治疗组：给予生理盐水30ml+顺铂60mg。注药后夹管并嘱患者变换体位，6小时后重新放开引流，待引流液体量每日少于50～100ml则考虑拔管。随后，每2周复查胸片或B超，2个月后观察比较两组胸腔积液量的变化、呼吸困难等症状改善、Karnofsky(KPS)标准评分变化和毒副反应。 结果 2月后结果显示：滑石粉联合顺铂组：完全缓解(CR)10例，部分缓解(PR)4例，无效(NR)1例，总有效率(CR+PR)93.3％；顺铂组：CR 2例，PR 9例，NR 7例，总有效率(CR+PR)61.1％，滑石粉联合顺铂组优于顺铂组，两组疗效比较有显著差异(P＜0.05)。患者呼吸困难等症状明显改善。治疗组KPS评分由60.00...

【英文摘要】 Objective: To observe the efficacy and toxicity of the talc combined with DDP in the treatment of malignant pleural effusion(MPE). Methods: 33 cases of pleural effusion were divided randomly.into two groups , the talc combined with DDP group( treament group) and DDP group( control group).There were 15 patients in the talc combined with DDP group,the other were 18 patients in DDP group. A chest drain(central venous catheter) was inserted in all patients.The adminisatration was performed when the chest cav...