【中文摘要】 乌贼墨的主要化学成分是黑色素和蛋白多糖复合体，具有显著的生物学作用。本文研究了乌贼墨对正常及骨髓损伤模型小鼠造血机能的影响，对小鼠的抑瘤和免疫调节作用，及其对实验性高脂血症大鼠血脂代谢和抗氧化能力的影响。 通过体内给予不同剂量的乌贼墨，采用造血祖细胞体外培养技术及实验血液学技术，观察乌贼墨对正常小鼠及环磷酰胺(Cyclophosphamide，Cy)或全身一次性接受致死剂量的γ~(60)Co照射所致造血损伤模型小鼠骨髓有核细胞数(BMNC)、骨髓造血干细胞生成数(CFU-S)、粒-单系祖细胞集落生成数(CFU-GM)、外周血白细胞(WBC)、红细胞(RBC)，血小板(PLT)，血红蛋白(Hb)和网织红细胞数的影响，并对其可能的作用机制进行探讨。结果表明，乌贼墨能够显著提高正常小鼠BMNC、CFU-S、CFU-GM和外周血WBC数量；对Cy损伤模型小鼠BMNC、CFU-S、CFU-GM和外周血WBC数量的减少具有显著的拮抗和促进恢复作用；能够有效拮抗β~(60)Co辐射损伤模型小鼠体内BMNC、CFU-S、CFU-GM、外周WBC及血清SOD活力的降低，并显著促进其恢复；对正常小鼠和模型小鼠外周...

【英文摘要】 The main chemical composition of sepia is melanin and protein-polysaccharide compound, which has obvious biological effects. The effects of sepia on hematophoiesis function in normal mice and in model mice of the bone marrow depression, the inhibitory effects of sepia on the transplanted tumor of Sarcinoma180 and immunoregulatoion functions, the effects of sepia on blood lipid and peroxidative levels in serum and tissue of hyperlipidemia rats were investigated. Sepia at different dose were given to norma...